Identification of responders to immune checkpoint therapy: which biomarkers have the highest value?
نویسندگان
چکیده
منابع مشابه
The future of immune checkpoint therapy.
Immune checkpoint therapy, which targets regulatory pathways in T cells to enhance antitumor immune responses, has led to important clinical advances and provided a new weapon against cancer. This therapy has elicited durable clinical responses and, in a fraction of patients, long-term remissions where patients exhibit no clinical signs of cancer for many years. The way forward for this class o...
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BACKGROUND Cancer of unknown primary (CUP) accounts for approximately 3% of all malignancies. Avoiding immune destruction is a major cancer characteristic and therapies aimed at immune checkpoint blockade are in use for several specific cancer types. A comprehensive survey of predictive biomarkers to immune checkpoint blockade in CUP were explored in this study. METHODS About 389 cases of CUP...
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Ipilimumab is a monoclonal antibody directed against CTLA4 T-lymphocyte antigen used as cancer therapy. Immune-related adverse events are common side effects and may include hypophysitis-related hypopituitarism. The clinical features of six patients with ipilimumab-induced hypophysitis (IH) are described. The clinical features of IH reported in clinical trials, including the incidence of IH by ...
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ژورنال
عنوان ژورنال: Journal of the European Academy of Dermatology and Venereology
سال: 2019
ISSN: 0926-9959,1468-3083
DOI: 10.1111/jdv.15992